IJCsatellite IJCsatellite/PRL

Phys. Rev. Lett. 94, 198302 (2005)

Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule

Wei Min,1 Guobin Luo,1 Binny J. Cherayil,1 S. C. Kou,2 and X. Sunney Xie1

1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
2Department of Statistics, Harvard University, Cambridge, Massachusetts 02138, USA
(Received 6 October 2004; published 18 May 2005)

The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photoinduced electron transfer and found to be a stationary, time-reversible, and non-Markovian Gaussian process. Within the generalized Langevin equation formalism, we experimentally determine the memory kernel K(t), which is proportional to the autocorrelation function of the random fluctuating force. K(t) is a power-law decay, t-0.51±0.07 in a broad range of time scales (10-3?10 s). Such a long-time memory effect could have implications for protein functions.

?2005 The American Physical Society

URL: http://link.aps.org/abstract/PRL/v94/e198302

doi:10.1103/PhysRevLett.94.198302

PACS: 82.37.-j, 02.50.-r, 05.40.-a, 87.15.He


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