[[IJCsatellite]]  [[IJCsatellite/PRL]]
 
 Phys. Rev. Lett. 94, 198302 (2005) 
 
 Observation of a Power-Law Memory Kernel for Fluctuations within a Single Protein Molecule
 
 Wei Min,1 Guobin Luo,1 Binny J. Cherayil,1 S. C. Kou,2 and X. Sunney Xie1
 
 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA~
 2Department of Statistics, Harvard University, Cambridge, Massachusetts 02138, USA~
 (Received 6 October 2004; published 18 May 2005)
 
 The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photoinduced electron transfer and found to be a stationary, time-reversible, and non-Markovian Gaussian process. Within the generalized Langevin equation formalism, we experimentally determine the memory kernel K(t), which is proportional to the autocorrelation function of the random fluctuating force. K(t) is a power-law decay, t-0.51±0.07 in a broad range of time scales (10-3?10 s). Such a long-time memory effect could have implications for protein functions.
 
 ?2005 The American Physical Society
 
 URL: http://link.aps.org/abstract/PRL/v94/e198302
 
 doi:10.1103/PhysRevLett.94.198302
 
 PACS: 82.37.-j, 02.50.-r, 05.40.-a, 87.15.He

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